BIO271H1 Lecture Notes - Lecture 3: Soft Palate, Sensory Neuron, Taste Receptor
Document Summary
Lecture 3 (january 27, 2016): sensory physiology: chemoreception. Found on tissues which are not that important for fight or flight like the skin and kidney. Blood vessels leading to those tissues are vasoconstricted. Found on presynaptic cell membrane: ne (norepinephrine) binds to receptors on presynaptic terminal. Stops production of camp, inactivates pka, inactivates calcium channels, so calcium no longer enters the presynaptic cell. More sensitive to ne: beta type. Ne binds, activates g-protein, activates adenylate cyclase, cleaves. Atp to amp, activates pka, phosphorylates calcium channels, calcium goes into the cell, calcium binds to troponin, myosin can then bind to actin. In the heart, this leads to a greater force of contraction to push more blood to the tissues. Found in blood vessel leading to the tissues that we need for fight or flight (like skeletal muscles) Alzheimer"s is treated with acetylcholine esterase inhibitors.
