BCH210H1 Lecture Notes - Lecture 22: Christian Bohr, Peptide, Fetus
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BCH210H1 Full Course Notes
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Hemoglobin and myoglobin: oxygen dissociation curves, 2,3-biphosphoglycerate, h+, co2 effects. For andreopoulos" section: chapter 12 (except non-linear. Classic example of allostery --> you can modulate something at an allosteric site. Hemoglobin and myoglobin are oxygen transport and storage proteins, respectively. Myoglobin is a storage molecule that stores oxygen in case of low o2 conc in tissues. Compare the oxygen binding curves for hemoglobin and myoglobin. H(cid:271): two (cid:272)hains of (cid:1005)4(cid:1005) residues, (cid:1006) (cid:272)hains of (cid:1005)46 residues. Exists in both hb (four) and mb (one) Has a central ion in the middle - fe2+ - this is the ferrous state. Without the iron is shown on the left. Makes four connections to the n of the ring. Oxygen can bind in this state, but not the fe3+ state. Composed of 4 pyrrole rings linked by methene bonds. Iron interacts with six ligands in hb and mb. Four of these are the n atoms of the porphyrin.
