BCH210H1 Lecture Notes - Lecture 33: Allosteric Regulation, Covalent Bond, Adipose Tissue

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

In order for anabolic processes to take place they need energy. Acetyl coa carboxylase (acc: contains a biotin cofactor and requires atp, cytosolic, polymeric enzyme that carrier out two reactions, carboxylation of biotin using atp, transfer of carboxyl group to acetyl coa, activated by, citrate (export of acetyl coa. Inactivated by: phosphorylation and palmitoyl-coa (final fatty acid product, 16 carbon chain, final product & can inactivate allosterically. Acc regulation: can be regulated 2 ways, allosterically, phosphorylation. If there is a high concentration of citrate present can overrule the inactive state: can still make fatty acid chains when glucagon signaling occurs but high levels of acetyl coa are present. Inhibition of acyl coa import and - oxidation (reverse pathway: malonyl coa inhibits carnitine acyltransferase i, slows down the reaction of fatty acid import and breakdown. Insulin and protein phosphatase activate acc via dephosphorylation: both pathways cannot be on at the same time.