BCH210H1 Lecture Notes - Lecture 32: Acyltransferase, Thiolase, Pyruvic Acid

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Triacylglycerol (triglycerides: principle stores energy reserve, stored in the adipocyte cells, stored in saturated bonds for close packing, easier to breakdown when needed if no double bonds. Prolonging fat mobilization via camp: caffeine inhibits the enzyme that turns camp into amp, concentrations of camp are high in the adipose tissues, continue to break down the fats. Fat metabolism overview: albumin is the carrier molecule to other cells to be broken down in fatty acid oxidation, acetyl coa will enter the krebs cycle and atp will be made by oxidative phosphorylation. Mitochondria structure: catabolism of fatty acids takes place in the mitochondril matrix, acyl coa cannot pass through the inner membrane, molecules can diffuse into the intermembrane space through the porins. Coenzyme a: largely negatively charged molecule, cannot cross the inner membrane. Carnitine shuttle: need to get acyl coa into the matrix, transfer the acyl group from coa to.