BCH210H1 Lecture Notes - Lecture 31: Peptide, Glycerol Kinase, Triosephosphate Isomerase

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BCH210H1 Full Course Notes
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BCH210H1 Full Course Notes
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In the absence of oxygen, oxidative phosphorylation cannot occur in the mitochondria and pyruvate is converted to lactate, replenishing nad+ Anaerobic metabolism: during periods of limiting oxygen, anaerobic metabolism occurs, glycolysis is the only means of generating atp, lactate dehydrogenase depletes nadh levels so no. Atp is made from nadhcyt by oxidative phosphorylation: this reaction does however, replenish nad+ for glycolysis to continue, muscles consume large amounts of glucose during exercise and release large amounts of pyruvate. Glucose + 2 adp + 2pi 2 lactate + 2 atp + 2 h2o. In yeast, two consecutive reactions produce co2 and ethanol, and also replenish nad+ for glycolysis: use pyruvate to make ethanol, using the nadh that was made in glycolysis. Oxaloacetate + adp + pi: pyruvate is a tetrameric enzyme, bicarbonate is used in the reaction, nucleophilic attack of bicarbonate oxygen at the gamma phosphate of atp, allosterically activated by acetyl coa.

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