BCH210H1 Lecture Notes - Lecture 15: Oligosaccharide, Transmembrane Protein, Micelle

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

If it goes all the (cid:449)ay thru the (cid:373)e(cid:373)(cid:271)ra(cid:374)e, its i(cid:374)tegral. I(cid:374)tri(cid:374)si(cid:272) protei(cid:374)s do(cid:374)"t go all the (cid:449)ay thru, (cid:271)ut they are loosely associated with the membrane. These membranes are defined by how we can get rid of them. Some sit on the surface and they interact with the head groups of the lipids. They have a hydrophobic loop that enters the membrane. If the protein can be removed, its loosely associated with the membrane. When we add salt, na goes to the negatively charged ion and chloride goes to the positive charged ion, shielding the charges. Usually (cid:449)e (cid:272)ha(cid:374)ge (cid:271)oth the salt a(cid:374)d the ph (cid:271)e(cid:272)ause its rarely o(cid:374)ly (cid:1005) (cid:272)harge that"s holdi(cid:374)g it together. These helixes are in the membrane, but they do(cid:374)"t go (cid:272)o(cid:373)pletely through. These proteins are anchored in the bilayer, they can move around. We add detergents that form micelles which pull the membrane proteins out of the membrane.