BCH210H1 Lecture Notes - Lecture 22: Nfkb1, Storage Protein, Hemoglobin

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Both molecules can carry oxygen, and they carry it via heme. Without the iron, its called porophorin, and nh-c=c-c=c-nh is a pyralle ring. When we have iron in the middle of the ring, its called heme. When iron is in the ferris state, it can bind o2. Iron can make 4 bonds, but it makes a total of 6 coordinate bonds,. Myoglobin has 1 of these molecules, hemoglobin has 4. The histidine that makes the 5th bond is a proximal histidine. When o2 molecule makes the 6th coordinate bond. Its all alpha helical, theres 8 alpha helixes that make up the protein, and the red thing is the heme. Heme fits into the 3d pocket, and its held together by nonco(cid:448)ale(cid:374)t i(cid:374)tera(cid:272)tio(cid:374)s. it"s a (cid:448)ery hydropho(cid:271)i(cid:272) (cid:272)left. Myoglo(cid:271)i(cid:374) is fou(cid:374)d i(cid:374) (cid:373)us(cid:272)les, it"s a great storage protei(cid:374). 2,3 bpg is also in rbcs wihc is an isomerase. Theres 2 alpha subunits and 2 beta sununits.