BCH210H1 Lecture Notes - Lecture 2: Alpha Helix, Beta Sheet, Glutamine

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Hydrophobic (non-polar) amino acids: ala, cys, ile, leu, met, phe, val. Hydrophilic (polar) amino acids: basic arg, lys (positive charge at neutral ph, acidic asp, glu (negative charge at neutral ph, polar asn, gln, his (amide versions of asp/glu) Ser, thr: tyr, trp, gly can be on the inside or outside of proteins, pro. Small changes in ph have a profound effect on hydrogen ion concentration. Zwitterion form of amino acids: amino acid free in solution, zwitterionic form neutral, but has two charges at ph 7. If you lower ph can protonate the. Coo- group: more proteins are available at low ph. Scales are different due to different methods used by scientists: take side chain equivalent of amino acid (benzene of phenylalanine) and measure where, don"t need to memorize numbers or scale, just know what is polar/charged/nonpolar. Trypsin surface charge basic (blue), acidic (red: the surface of the enzyme trypsin (made in the intestine)