BCH210H1 Lecture Notes - Pi Bond, Chemical Bond, Acid Dissociation Constant

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Lecture 2: ionization, ph, titration curves, acid- base chemistry, amino acids. All molecules or ions with a free pair of electrons or at least one pi bond can act as nucleophiles. Start with 2 amino acids remove a water molecule = formation of cn- nh bond (amide linkage) Water can ionize to form a hydronium molecule. Properties of water electrical polarity (net dipole) highly cohesive (attracts h2o molecules) solvates polar molecules (ex. Ammonia) and weakens ionic ones (electro static molecules, ex. Quantify the ionization of water keq= ration of [] products vs. reactants in a reaction. Dissociation of weak electrolytes consider a weak acid, ha the acid dissociation constant is given by: Weak acid low ka, high pka. Titration curve of acetic acid. Titration curve of phosphoric acid you need 3 molar equivalents to titrate phosphoric acid from h3po4 to hpo42. 3 pka values, 3 ionizable groups, 3 molar equivalents needed. 3 buffering regions (3 inflections)