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Lecture 17

BIO241 Lecture 17

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University of Toronto St. George
Jennifer Harris

Tuesday March 10 2009 This week were going to discuss the extracellular matrixhow cells can crawl on that extracellular matrix to drive cell mobility Last week we learned about cell junctions in bw epithelial cells We saw that there were 3 different types that there were anchoring junctions that connect the cells together that there are sealing junctions occluding junctions called tight junctions which seal the gap in bw these cellsalso that there are gap junctions which allow for communication bw these cells All of these junctions are found on the lateral side of an epithelial cell We learned how the apical side of that cell will face the lumen of an organ or the outside of the body This week were going to be discussing what is going on at the base of these cellswhat is this connective tissue below the cells that these cells are sitting on Here is a cartoon of what it looks like right herewhat were looking at is this would be the basal plasma membrane right here so the base of the cellhere in green these are receptors from the cell that are reaching out through that plasma membrane transmembrane proteins so thats why theyre poking out through these holes here These receptors reach outcontact this matrix of different types of proteinsthis is what is called the extracellular matrix So weve learned that cells interact with each othertoday well talk about how they also interact with noncellular extracellular material Diagram This is the extracellular matrix This is a proteinsugar network in the extracellular space Fibroblasts Diagram This is a fibroblast circled in red Here is our epithelium along the topso above this epithelium could be the lumen of an organ the lumen of the stomach or it could be the outside of the bodythen when you go in from that epithelium then you enter this region of connective tissue here So this contains the cells that make that connective tissue the fibroblasts but this is also where youd also find your muscle cells the neurons the immune cells for example here is a macrophage a white blood cell that may have left the bloodstream here is a capillary running through this extracellular matrix that may have left this to gofight an infection like we learned about last day So weve learned about epithelia neurons muscle cells immune cells Here were talking about the extracellular material that all these cells are interacting with
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