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Jean Jiang Nash

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LECTURE 6 Protein sorting through the secretory pathway Transfer of proteins into ER lumen ER has translocators embedded in membrane allow for proteins into lumen From rough ER to Golgi apparatus to other organelles through vesicles ER first in pathway Proteins synthesized into lumen of ER become part of inside of lysosome or inside of ER or secreted outside of cell Lumenal leaflet is similar to extracellular face of cell ER is dynamic, a network of tubules that form connections and break old ones Protein sorting to the ER In drawining mRNA in blue and green ribosome; nascent polypeptide synthesizing ER signal sequence first translated Synthesis and modification of proteins Synthesis of lipids (smooth ER Have ER signal sequence mRNA +ribosomes Constantly coming to ER membrane and then leaving Hydrophobic amino acids at N-terminus Model: Protein sorting Bind GTP Low affinity High affinity Ribosome Receptor embedded in the membrane Translocon in blue Gated channel o Closed until ribosome is bound to it, translaiting protein into lumen of ER Prevent diffusion of ions, small molecules GTP hydrolysis Complex dissociates The red signal sequence remains there in the membrane ER signal sequence Start-transfer sequence Cleaves ER signal sequence o Eventully degraded Translocator gated in 2 direction
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