Class Notes (837,539)
Canada (510,303)
Biology (2,229)
BIO120H1 (1,171)
Lecture

Notes taken during lecture

3 Pages
122 Views
Unlock Document

Department
Biology
Course
BIO120H1
Professor
Jean Jiang Nash
Semester
Winter

Description
LECTURE Feb. 152011 Cell signalling pathways in quite a bit of detail for today Each pathways unique protein involved, signals involved Different signals different responses to each G-proteinlinked receptor GTPase complex receives signal Alpha swaps GDP to GTP Dissociate No signal alpha bound to GDP off Receptor activated induces conformational change in alpha subunit, which causes GDP to dissociate, and GTP binds in its place GTP binding causes further conformational change o Activated alpha subunit dissociates from beta and gamma Both can now regulate activity of target proteins Target proteins convey signal to other proteins Prolonged stimulation receptor becomes inactive, even if ligand is bound Arrestin bound to receptor on cytosolic side Receptor either endocytosed for degradation or it can be recycled for further use to its pathway OUTPUT o cAMP activates PKA indirectly, since PKA exist bound to inhibitory molecules, and cAMP causes inhibitory molecules to fall off phos
More Less

Related notes for BIO120H1

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit