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Jean Jiang Nash

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LECTURE 13 CELLULAR ARCHITECTURE AND THE FORMATION OF TISSUES how cells interact to form complex 3d shapes? Loss of control cell tumours form proliferate too much change from benign to metastatic tumour For the exam, responsible for material in the TEXTBOOK AND THE LECTURES Find what was covered in lecture in the readings, and make sure this is know Before coming into lecture, read the captions of the figures in the readings figure out what they mean Cytoskeletal machinery Goblet cell specialized shape, structure, filled with vesicles containing mucus that is secreted from cell o Shape depends on cytoskeleton, which allowed the cell to specialize Sperms cytoskeleton allows it to specialized into swimming Rod cell has membrane folding apparatus at top that capture photons o Photon information can come out of the synactic region at the end of the cell o Due to the cytoskeleton, attachment between cytoskeleton and the membrane allowing cells to have different functions Microtubules attached to chromosomes, during mitosis separate chromosomes Make sure segregate evenly into two cells Cell-cell interactions reason behind tissue strength Proteins embedded in plasma membrane can be pulled out hydrophobic interactions not very strong But inside the cell, the proteins sticking cells together are attached to cables Blue part is the cell attachments adhesion complexes Intermediate filaments in green o Inside the cell o But attached to adjacent cell huge protein interaction network, making this entire thing into a strong tissue o Because of these intermediate filaments, skin is supple, can be deformed but not broken STRUCTURAL function Lot of dynamnics in cell must be regulated Cytoskeleton can be very dynamic and is highly regulated Can migrate if it must Acting like cables for o Vesicles moving on cables, o Filaments have polarity so movement can be in one direction or other
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