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Jean Jiang Nash

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th LECTURE 15 March 8 Microfilaments cell adhesion Intermediate filaments independent Cytoskeletal networks are dynamic especially microtubules, which can lengthen and shorten But there are others who are not dynamic, but static Cell junctions 3 types: anchoring junctions like Velcro; occluding junctions like Ziploc; Anchoring junctions: mechanically attach cells to cells or the extracellular matrix Occluding junctions: seal the contacts between cells o Prevents material from passing btw cells Channel forming junctions: allow small molecules to pass from cell to cell Todays focus is anchoring junctions ANCHORING JUNCTIONS Circle is the cell on average, 50 micrometres across o Dot beside it is a protein, a cell adhesion protein To adhere cell to adjacent cell, to adhere to the matrix Cell adhesion proteins are clustered into groups, which increase strength of interaction between cell o Many stronger than one o Velcro effect: o Pulling on whole network, not just hydrophobic interaction Affinity: the binding strength between two molecules via a single binding site Avidity: the TOTAL binding strength between two molecules or complexes, involving multiple binding sites o Note the multiple binding sites Avidity greater than sum of parts because of the Velcro effect o Interaction represented by red line o Frequency of binding or releasing built into affinity concept o As for avidity two proteins linked together at top two binding sites With same rate of loss and binding instead of floating away, held close to protein partner likely to bind to its protein partner Note that one arrow is darker One is likely to break, the other is going to form rightaway Must have both bonds broken together to totally separate If one Velcro hook disengaged, still majority engaged Cytoskeletal attachments Adherens cell-cell
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