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University of Toronto St. George
Jean Jiang Nash

LECTURE 18 Elastin Flexible tissues (ex. blood vessels, lungs) o Lungs stretches, inflating ECM full of elastin fibres o Green proteins linked covalently so when stretch out, will not separate o Coil and stretch and coil and stretch Self-assemble into elastic network outside cell Basal lamina Thin and flexible Basal surface of epithelial cells attached to it via focal adhesion contact Lumen is always apical and also apical is outside body Figure 19-53 KNOW IN DETAIL o Fibroblast can migrate not just white blood cells o Both have ability to modify ECM by secreting and modifying activity of proteases Blistering diseases when basal lamina doesnt function properly Muscular dystrophy muscle loses attachment When cannot attach cells properly to basal lamina, disease result Physical attachment comes through transmembrane protein Fibronectin and laminin are linker proteins Link ECM to transmembrane proteins on cell surface Laminin Molecule made of 3 proteins Folded into coiled coil Heterodimer What is interacting with what? o Self assembly is how laminin stick to laminin to form large complexes o Integrin and laminin attach to lamin to matrix o Dystroglyan can perlecan are what Binds to Type IV collagen, perlecan and nidogen Binds to integrins ECM and cell surface fibronectin Important during gastrolation B is fibronectin dimer held together by disulfide bridges Two forms o Soluble form found in blood If cut self, activated to form network clotting o Fibrilar form normal form involved in cell to matrix interactions in normal tissues
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