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Lecture 13

BIO241 Lecture 13

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Department
Biology
Course
BIO120H1
Professor
Jennifer Harris
Semester
Winter

Description
BIO241 Lecture 13 Cytoskeleton - cytoskeletal machinery controls cell shape, interactions and numbers - cytoskeletal networks provide structural frameworks for cells, very dynamic and highly regulated, can be remodelled broken down and rebuild again so cell can change its shape - functions: o cables for intracellular traffic, chromosome separation during mitosis, cytokinesis, mechanical strength (transduce force) o poles: forming cell protrusions (protrusive force), filopodia and lamellipodia for cell migration (forward translation) , stereocilia in sensory cells - made of filaments composed of small protein subunits, gives dynamic property, allows them to breakdown and rebuild quickly, small soluble subunits can form large filamentous polymer and the reverse is true - three main networks of filaments o microfilaments: actin monomers o microtubules: tubulin monomers o intermediate filaments: many different types, e.g. keratin in skin - filament nucleation is rate-limiting step in filament polymerization o short ol
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