BIO130H1 Lecture Notes - Lecture 16: Endosome, Endoplasmic Reticulum, Endomembrane System
31
BIO130H1 Full Course Notes
Verified Note
31 documents
Document Summary
The internal signal sequences cant be cut off. The signal sequences on the ends end up in the endoplasmic reticulum, the signal sequences in the middle end up in a different location. The translocator protein ckhecks the neighbouring amino acids to see which side is more negative and which side is more positive. The n terminal side will stay facing the er lumen, and the rest of the protein will be made into the cytosol. If the er lumen side is more positive, the n terminus is flipped out to face the cytosol, and the rest of the protein faces the er lumen. This makes the positive side face the cytosol and the negative side faces the er lumen. Depending on their orientation in the er, it will stay consistent throughout the moving process. Proteins & lipids ae transported from the er to the golgi apparatus. Vesicles transport proteins/lipids from the er to the golgi apparatus.
