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Lecture 5

Molecular Biology of the Cell - Lecture 5 Readings

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University of Toronto St. George
Jane Mitchell

Adaptive Biology The Molecular Biology of the Cell Chapter 5DNA Replication Repair and Recombination y Mutation a random change in the genetic information DNA o Fibrinopeptidesfragments of 20 amine acids that are discarded when the protein fibrinogen is activated to form fibrin during blood clottingSince the Fibrinopeptides can tolerate almost any amino acid change this is used to calculate the mutation rate of germ lines y Low mutation rates allow for the complexity of life that exists on Earth today o The mutation rates among many different and diverse species is the same o High fidelity when transporting genetic information from parent to offspring y DNA Templating the method by which DNA replicated itself y DNA Polymerasenucleotidepolymerizing enzyme o DNA is said to be semiconservatively replicated because the daughter cell gets one old strand and a new strand o The DNA helix is split and each 5 and 3 strand is used as a template to form a new strandReplication Fork The area wherein the replication occur it contains a multienzyme complex that completes the jobReplication occurs discontinuously on the Lagging Stra
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