BIO130H1 Lecture 5: Molecular Biology of the Cell - Lecture 5 Readings
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BIO130H1 Full Course Notes
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replication fork: the area wherein the replication occur; it contains a multi-enzyme complex that completes the job. replication occurs discontinuously on the lagging strand, and continuously on the. Dna y replication in the 3 to 5 direction leads to higher mutation rates; thus 5 to 3 is the chosen replication direction. dna primase: lays down the rna primers onto the lagging strand. single-stranded dna binding proteins: keep the dna from re-annealing. dna polymerase i: removes rna primers on the laggings strand and replaces them with the proper nucleotide base pair. dna ligase: forms phosphodiester bonds to link the fragments together on the lagging strand y. a clamp loader; is the special protein complex that binds the clamp to the dna using. Atp hydrolysis y all the separate proteins above act in unison together in a big protein complex that replicates the dna.