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BIO130H1 (434)
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Tutorial Notes 1

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Department
Biology
Course
BIO130H1
Professor
Jane Mitchell
Semester
Winter

Description
TutorialFebruary 2 2012Replication Bubble Formationreplication moves in both directionschromatinbubble gets bigger and biggertwo sets of replicationnot moving on strand just spreading apartone replicon with leadinglaggingon other side another replicon with leadinglagging strandtwo polymerases in opposite directionseach replicative machinery complex is doublesone for eachindependent originsDNA primaseligase would just fill in gaps in the endspecific sequences that characterizes the originusually AT rich must be recognized by protein complexes easily prokaryotesAfter cell divisionwhat regulates telomeric growthcellssynchronous populationclonal cellaround 3540 divisions cells are mostly synchronizedby this many divisions telomerase replicative capacity reducedstem celltelomerase activity maintainedused to keep all cell lines immortalHow does stem cell know it needs to make more telomerase to continuesensory mechanismcomplicated widely unknownCancer Tumourscancer tum
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