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Lecture 3

Lecture 3.docx

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Jane Mitchell

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Lecture3 Ppt3 *The permeability is basically how the molecules interact with the tail of lipids. *hydrophobic molecules easily pass the bilayers *uncharged, small, polar molecules are not easy to pass the bilayer.. *Movement via simple diffusion through the lipid bilayer 1) High concentration to low concentration – 2) More hydrophobic or non-polar the molecule The ions need a specific membrane protein to pass the bilayer (for their transport): membrane transport proteins Ppt 5 [Membrane Transport Proteins] *multipass transmembrane proteins –protein-lined path across cell membrane -Transport the charged molecules ex)ions, sugars, amino acids, nucleotides, various cell metabolites •different cell membranes –different compliments transport proteins •each transport protein is selective so it transport a specific molecules Ppt 6 *Chaneel-mediated: they are passive but sometime they are gated.(열고 닫아) *transporter mediated: passive: always move down, no energy required. Active: move molecule in opposite direction(against the concentration radient). Requires energy. Ppt7 Iclicker question ANS: C (the negative charge of the inside motivated the movement of the positively charged molecule) Ppt8 *when there is no charge on the membrane, we will just consider the concentration( high to low) But if there is charges on the membrane,,, we need to condiser the lectrochemical gradient( the opposite charge of the molecule lining the inside motivating the movement of molecule though the bilayer) So for charged molecules… Not only concnetraion gradient but also the electrochemical gradient is important. Ppt10 LEC2001.LEC5101.LEC0101/membraneTransport.swf Ppt11 [types of active transport] *active transport is against electrochemical gradient: it needs energy 3types: 1)coupled transporters: one molecule moving down the gradient, this provides energy for the one to move against the gradient 2) ATP-driven pumps (―Pumps‖ or ―ATPases‖) Use ATP (ATP---ADP) to move molecules against the gradient. Ex) sodium potassium pump 3) Light-driven pumps (bacteria) Use light energy to move against the gradient Ppt12 Ppt13 [Transporter Proteins] -bind to a specific solute -undergo a conformation change to move the molecule across the bilayer -transport solute across membrane The molecule is shielded by the protein from the hydrophobic environment Ppt 15 [Passive transport by transporter proteins---Uniporter (esp. GLUT Uniporter)] *Passive uniporter: moves one molecules down a electrochemical gradient *direction is reversible by the ―electrochemical gradient‖ without any input of energy *it depends on the direction of electrochemical gradient *GLUT Uniporter is usually from outside of the cell to the inside for the cell since it is an important nutrient. Ppt17 *GLUT Unipoerter: transport a glucose down a concentration gradient(glucose is uncharges) *glucose is generally high outside of
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