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Lecture 4

Lecture 4.docx

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Jane Mitchell

Lecture 4 Ppt28 *2 common things happening in ATPase (pumping mechanism) 1) conformational change of the transport protein 2) use of ATP (phospho-related) Ppt30 Ppt31 *Gut is unique cell,, polar,,one side of the cell has opposite charge..…rapidly dividing *One side of the cell has different protein for the other side of the cell -Apical side of the cell(lumen of intestine): take nutrient into the cell -Basal side of the cell: take nutrient from cell to the blood vessel *Proteins are mobile in the cell membrane…but how there are two different membrane? ----―tight juction‖ it acts like a belt that does not allow any movement though the point. It seperates the apical domain form the basal domain of the cell. *since the intestinal epithelial cells wants to take in the glucose from the intestinal lumen as much as possible though the concentragion of glucose is already high…. Glucose now moves against the concentration to move into the cell……to do that Na+/Glucose symporter found in apical plasma membrane….. to maintain low level of Na+ inside the cell, the Na+/K+ pump happens at the basal membrane of the membrane……. and on the basal domain, the glucose needs to move into the blood stream, GLUT Uniporter is used. (basal domain=basolateral membrane) Iclicker What happens to red blood cells when they are placed in a hypertonic (삼투압이 높은, 배추 절이는거 생각해) solution? A) They swell and burst B) They shrink (hypertonic: higher solute concentration (즉 low water concentration) outside the cell) Ppt33 [ATP-driven pumps (transport ATPases--- F-type and V-type ATPase& ABC Transporters) *Type II active transport proteins (Proton pump) (terbinal rotation action) F-Type (e.g. ATP synthase): - use the H+ gradient to drive the synthesis of ATP - found in mitochondria, chloroplasts, bacterial outer membrane V-Type (e.g. H+ pump): - use ATP - pump H+ into organelles, acidify the lumen - found in lysosome, plant vacuole They are reverse to each other.?! Ppt37 [ABC Transporter] *Use 2 ATP to move a molecule against the gradient *they are not specific *MDR I: blood& brain 갂의 교류를 위한거였는데.. 주로 암치료의 방해가 되고있네.. Ppt39 [Channel Proteins (passive transport)) *they do not have cycling action They are gated, they can be open and close *most of them are highly selective though they are not binded to a certain molecule *they work faster (since several molecules can go though when it is open) than the transporter proteins. Ppt40 [Ion channels] *Found in animals, plants, microorganisms *Two types: 1) Non-gated – always open e.g. K+ leak channels. Major role in generation of resting membrane potential in animal cells 2) Gated (openl and close)– chemical or electrical signal required for channel opening Ppt41 [Non-gated ion channels] e.g. K+ Leak Channels *generally K+ moving out of the cell *found in the plasma membrane of animal cell * the membrane potential motivated the movement of K+ into the cell when the inside of the cell is negatively charged (reverse) *found on plasma membrane of animal cells *general role is generating membrane potential across plasma membranes (animals) Ppt42 [Membrane Potential] *Membrane Potential : Difference in the electrical charge on two sides of the membrane *Importance (e.g.): -used by symporters and antiporters to ca
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