BIO130H1 Lecture Notes - Lecture 7: Neutrophil, Polymerization, Phalloidin

• School: UTSG
• Department: Biology
• Course: BIO130H1
• Professor: Jane Mitchell

Document Summary

[the cytoskeleton:: provides structural support, positions organelles, directs vesicular transport, involved in locomotion (ex)sperm cell w flagella tail,, cell crawling, required for cell division. *(the cytoskeletons) cilia, flagella are close structure for moving. [three types of filaments form the cytoskeleton: microfiloaments: [limits of light microscopy: the light microscope has a resolution limit: ~250 nm (microtubules have a diameter of 25 nm) So can"t see the structure of cytoskeletons: electron microscope: Resolution: <10 angstroms (better resolution) (>250x better resolution) Examples of the functions that requires the dyamics: for cell motility/crawling the actin filaments must rapidly: At the leading edge(where lots of movement is happening) For this the actin should be very dynamic: microtubules: Most interphase microtubules radiate in the center but for cell division to the poles. Are reorganised to form the bipolar mitotic spindles in dividing cells. * so the subunits form as a filaments. You have three drugs that interact with components of the cytoskeleton.