Class Notes (834,657)
Canada (508,678)
Biology (2,228)
BIO220H1 (244)
Matthews (6)


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Pregnancy and birth and running a marathon Maternal lactation There are large numbers of milk producing Milk produced by epithelial milk secreting cells Myoepithelial muscle cells when cells contract squeeze milk out on alveoli into milk ducts Estrogen and progesterone inhibit action of prolactin in milk secreting cells Prl initiates milk production Ota acts on myoepithelial cells in milk duct to nipple Hormonal regulation of lactose Galactopoeisis Initiated by baby sucking Galactopoeitic effect Mechanoreceptors in nipple activated results in neuro-endocrine response Sounds baby crying cause higher activation Inhibition of dopamine in hypothalamus Inc.prolactin secretion from Anterior pituitary gland Prolactin activate milk production Production of milk is only part of process milk must be transported to site of production in alveoli to ducts to nipple = milk ejection reflex and controlled by OT OT secretion from maternal pituitary acts in myoepithelial cell to milk ejection In most mothers milk ejection reflex highly response cry and baby smells activates process It is important to provide relaxing nursing mothers to occur optimal ejection of milk Birthweight and Health in Later life? 180’s epidemiological work began to show correlation of birthwt. And later life Wt. food and health development of child Correlates birth and disease in later life. Fetal env. Influence life later Likelihood of dying against cardiovascular disease : Low birth wt. higher risk of developing CVD Rebound effect in 9.5 lbs – diabetic mothers – high glucose levels inc.risk factors for CVD Metabolic syndrome – metabolic condition – insulin insensitivity, diabetes Low birth wt. high metabolic syndrome risks Birthwt., cortisol, and BP CV and endocrine function Plasma cortisol levels against birthwt. Higher cortisol in lower birth wt. Increase cortisol assoc.with elevated BP Plasma cortisol conc. Hypothalamus – changes in this axis leads to disease in later life If
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