BIO230H1 Lecture Notes - Lecture 4: Histone Code, Lysine, Acetyl Group

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20 Sep 2013
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BIO230H1 Full Course Notes
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I suggest you fluff my notes up with someone else"s because i don"t know how complete they are. Also, the notes only make sense when read along with the slides. If something"s on the slides, it probably isn"t in my notes. fx = function btw = between. Transcription initiation in eukaryotes requires many proteins: general transcription factors these help position rna polymerase at eukaryotic promoters: contain tata box required by nearly all promoters used by: Have a modular design (have two modules that carry out two separate fxs) 1. modular design: dna binding domain co activator does not have this: activation domain. Accelerates the rate of transcription two domains that carry out separate fxs but can be mixed and matched to create chimeric assembly how do activator proteins activate transcription? attract, position and modify: Rna polymerase ii they can do this either: directly by acting on these components, indirectly modifying chromatin structure (prokaryotes do not have chromatin)

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