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Lecture 10

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School
University of Toronto St. George
Department
Biology
Course
BIO230H1
Professor
Darrel Desveaux
Semester
Fall

Description
Lecture 10: Protein Sorting BIO230 Oct 10, 2013 TRANSMEMBRANE PROTEINS single pass proteins go through membrane once and multi-pass go through membranes multiple times proteins have N and C terminus site of terminus determined during translocation C terminus can be at cytosol side or ER lumen side SINGLE PASS PROTEINS FIRST EXAMPLE ER signal sequence at N terminus protein delivered through translocon TM domain fxs as stop-transfer signal when TM domain emerges through, that will stop movement cleaved off by signal peptidase COOH in cytosol SECOND EXAMPLE - SINGLE PASS 2 transmembrane domain is rich in hydrophobic proteins so it can associate with hydrophobic environment in lipid bilayer TM domain internal start-transfer sequence (transmembrane domain) difference between internal start-transfer sequence is that it is not cleaved by signal peptidase orientation: amino acids on cytosolic face (that are positively charged) if you know where positively ch
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