BIO230H1 Lecture Notes - Lecture 11: Oligosaccharyltransferase, Transmembrane Protein, Glycosylation
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BIO230H1 Full Course Notes
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Document Summary
After a protein has entered the er via transmembrane transport, they can move to different cellular compartments through vesicular transport. Glycosylation occurs on most soluble and most transmembrane proteins in er. Occurs on serines and threonines in the golgi. There is a big precursor that exists preformed in the er; this is added onto an asparagine side chain. This precursor is made up of 14 sugar residues consisting of 3 glucoses, 9 mannoses, and. It is linked to a target protein in the er. In this case, this enzyme is responsible for transferring the precursor onto the growing side chain. Remember that this is a co-translational process so as the protein is being synthesized and delivered into the er, sugar modifications will be occurring. There is an amino acid sequence that is preferentially glycosolyated by n-linked glycosylation: it is asparagine, followed by any amino acid (except proline), and then serine or threonine.
