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Lecture 9

Bio230 Lecture 9 Textbook

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University of Toronto St. George
Jennifer Harris

BIO230H1 Lecture 9 Notes 921-931 Signaling Through Enzyme Coupled Cell Surface Receptors  Enzyme coupled receptors are transmembrane proteins with ligand- binding domain Activated Receptor Tyrosine Kinases (RTKs) Phosphorlyate Themselves  Many extracellular signals can be determined by receptor tyrosine kinases  RTKs can autophosphorylate  Dimerization can occur Phosphorylated Tyrosine on RTKs Serve as Docking Sites for Intracellular Signaling Proteins  Cross phosphorylation can occur; first phosphorylating the kinase domain then the kinase domain creates a docking site  RTK activate the signaling molecules Proteins with SH2 Domains Binds to Phosphorylated Tyrosine  Interaction domains: docked proteins  SH2 domains were bound Ras Belongs to a Large Superfamily of Monomeric GTPase  Ras superfamily small GTPase  Ras can cycle between GTP and GDP RTKs Activate Via Adaptors and GEFs Evidence from the Developing Drosophila Eye  Ommatidia unit: photoreceptor cells  R7 cell UV light detection  Bride of sevenless (Boss): encodes for a ligand Ras Activates a MAP  Ras can help activate activity through phosphorylation  Scaffold molecules help
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