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Lecture 4

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Chris Garside

Lecture 4October 2 2013316 PM BIO270 Page 1 Signalling cell has to reduce the signalling molecule or accumulate the signaling molecule its not going to make it itself That should be incorporated as well You have to send that signal and there has to be a target cell to receive and response to a signal If you dont have a target cell it doesnt have a receptor the chemical cant send the signal If the receptor binds the chemical and does change the cell the its not going to work It has to bind and response correctlyDirect signallingOne cell can move from one cell to another directlyCytoplasms are connected in two cells These are called gap junctions communicative junctions These are the key in heart muscles allowthe transfer of electrical charges so the heart beats as one Important for the ions to move to every cell Autocrine and paracrine signaling short distanceHave a short halflife Dont stick around for long Mechanisms to remove these molecules so they cannot move around anymore This is diffusion alone Diffusion between the signalling cell and the responding cell If the target cell is different from the signaling cellparacrine signallingIf the target cell is the same as the signaling cellAutocrine signalingOne cell sends signal which binds to the receptor on the same cell is Autocrine responseSignal binds to different cell receptor paracrine Endocrine when the signaling molecule is released into the blood Reaching distant targets Tend to have longer halflives than Autocrine and paracrine signals Have to travel a bit further And this makes sense if that happensNeural signal signalling cell been a neuron sends an electrical signal a long distance down an axonEndocrine signaling is long distance via circulatory systemNeuron signal is within the signaling cell long distance Electrical signaling releasing a chemical messenger into a synapse And this is diffusionThe synapse is similar to paracrine signalling We have short and long distance signaling These are all indirect signaling The molecules must be released from the signaling cell to get a response The direct signaling is not required They have to move through many of these gap junctions Those are ether types of cell signaling we have to talk about BIO270 Page 2
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