CSB327H1 Lecture Notes - Fibroblast, Cytosol, Adipocyte
21 Oct 2013
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Document Summary
Order of layers (from top down) epithelium bl ct. Epithelial cells are aware of connective tissue env. bc of basal lamina which communicates the environment to the cell. Loss of contact bw epithelial cell/bl/ct often causes blistering diseases via immunological responses. Introduction & overview of ecms and fibril-forming collagens. Tissue fibrosis = overproduction of collagen = harder tissues; bad for some organs e. g. don"t want heart to become more rigid/fibrotic. Ecm proteins consist of collagens, proteoglycans, glycoproteins found in all tissues: non-collagenous structural proteins are also a ecm protein (e. g. elastin, lamprin, egg shell proteins) but is mainly found in connective tissues. In addition to forming 3d scaffolds /w complex biomechanical properties, ecms have diverse regulatory fcns that affect the cell. Over time subset of ct can remodel quickly but under diff tensional forces the remodelling process may not bring ct back to original form.
