CSB327H1 Lecture Notes - Lecture 13: Tissue Plasminogen Activator, Tissue Inhibitor Of Metalloproteinase, Golgi Apparatus
1 Jan 2014
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Document Summary
Substrate specificity + structural organization of secreted mmps. Mmps large class of proteases which can target ecm molecules. Some proteases have type 2 or type 3 repeats, but type 3 repeats found on lots of ecm molecules which explains why mmps can attack more than one. Two types of mmps: membrane type mmps (mt-mmps) which are activated intracellularly by furins in trans golgi network, secreted pro-mmps which are activated by plasmin enzyme. Plasminogen = zymogen form of plasmin which can be activated by upa (urokinase- plasminogen activator) or tpa (tissue plasminogen activator) Serine proteases plasmin, upa, tpa (plasmin synonymous /w wound repair) Adam a disintegrin and metaproteinase; two types exist: secreted adam-ts = adam /w at least one thrombospondin (ts) repeat (integrin motif found @ end of secreted form, membrane bound adams form. Aminopeptidases (anps) exopeptidases which chew proteins from ends.
