CSB328H1 Lecture Notes - Lecture 24: Bone Morphogenetic Protein 2, Wnt3, Sox9

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Autopod: digits with interdigital zone in between the digits, alternating pattern. Whenever you have a maximum of the activator, there is also the maximum of the inhibitor: types of models. Activator and inhibitor are both in phase. Activator activates itself by depleting its substrate (still self- promoting) Whenever you have a lot of activator, there will be very little substrate. Does a turing-type mechanism cause the alternating pattern of digital and interdigital: activator and substrate are out of phase zones, sox9. Whenever there is high concentration on sox9, that is where a digit will form: sox9 expression in growing limb buds. Only have two peaks of sox9 expression. 4 peaks of sox9: number of digits increases with the increasing size of the autopod. This is what we expect if there is a turing type mechanism. Sox9 pattern shows self-organizing properties: isolated cells from autopod. Islands of sox9 positive cells with sox9 negative cells in between: fluorescent sorting, sox9 positive.

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