CSB331H1 Lecture Notes - Lecture 13: Neural Crest, Tooth Enamel, Peripheral Nervous System

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Neurogenesis and neural crest cell migration - lecture 13. Surface ectoderm (epidermis) --> skin and its associates structures. Epidermis, hair, nails, sebaceous glands, olfactory epithelium, mouth epithelium (anterior pituitary, tooth enamel, cheek enamel), lens/ cornea. Neural crest --> peripheral nervous system and pigment cells. Pns (schwann cells, neuroglial cells, sympathetic nervous system, parasympathetic nervous system), adrenal medulla, melanocytes, facial cartilage, dentine of teeth. Diverse contributions, must migrate distances, guidance cues: chemotactic and repulsive. Neural tube --> central nervous system and motor neurons. Brain, neural pituitary, spinal cord, motor neurons, retina. Nc cells undergo emt and delaminate from the neural tube/ectoderm border so they can migrate to distant locations in the embryo where they"re form. Peripheral nervous system (pns) and pigment cells (melanocytes) Nc cells are often referred to as the 4th germ layer due to the diverse cell types and tissues they form - however, they are not a germ layer.

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