CSB331H1 Lecture Notes - Lecture 16: Lateral Plate Mesoderm, Mesenchymal Stem Cell, Runx2
19 Apr 2017
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Endochondral ossi cation and blood vessel formation - lecture 16. Formation of cartilage and bone - endochondral bone formation. Bone formed though cartilage intermediate somite and lateral plate derivatives, vertebral columns, ribs. Endochondral ossi cation is for long bones such as ngers, feet, etc. Vertabrae, ribs from sclerotic and limb bones from lateral plate mesoderm. Neural crest derived bone: at bones of skull. Chondrogenesis is the rst template/skeletone that is made in our body (cartilage) Surface of skin has to be able to resist mechanical stress and this is largely due to cytokeletal elements. Chondrocytes, osteoblasts, broblasts are examples of connective tissue cells secrete abundant ecm, rich in collagens and reside within their secreted matrix provide the body"s architectural framework and tissue shape contribute to support and repair ~every tissue and organ. Weaving pattern and the matrices are binding a lot of growth factors with matrix remodelling. Mmps when tissues are forming disease states, such as cancer.
