CSB331H1 Lecture Notes - Lecture 7: Adapter Molecule Crk, Rhoa, Cofilin
4 Apr 2012
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Lecture 7 focal adhesion kinase and regulation of actin dynamics by rac1 january 31,2011. Focal adhesion kinase a regulator of cell adhesion, migration and anchorage dependent growth. The role of protein-tyrosine kinases (ptks) regulating focal adhesion. One type of signaling event stimulated by integrins is tyrosine phosphorylation of cytoskeletal as well as signaling proteins. However, since integrins do not possess catalytic activity, the signals initiated by ecm-integrin interactions must be transduced into cells through the activation of integrin- associated proteins. A number of different intracellular protein-tyrosine kinases (ptks) such as focal adhesion kinase (fak) and src-family ptks are activated by integrin clustering or cell binding to ecm proteins. Fak is a multifunction protein that affects a variety of cellular processes; the focus was on how fak is linked to intracellular signaling pathways controlling cell motility. Fak is often referred to in the literature as pp125fak, reflecting that fak is a phosphoprotein with a molecular weight of 125 kda.
