CSB332H1 Lecture 2: Lecture 2 - includes txtbk reading (pg. 144-146) notes & ATPase youtube notes
17 Jan 2012
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Csb332 l2 ch 4,5,6; jan. 11, 2012: allowed to post recordings on the portal discussion but, not anywhere else, 2 classes of recs. If ligand binds to channel & directly opens = ionotropic. If ligand binds to rec that initiates signal cascade that opens another channel = metabotropic: ach rec transmembrane, If looking from extracellular down: m2 lining pore, 5 subunits, a: channel closed, pore small, b: larger pore, m2 transmembrane-domain rotated outward, c: m2 close, closed, d: m2 move away from each other open. Youtube vid: psychologically & physical addiction to nicotine, dopamine production. In lungs, nicotine passes directly from epithelium into bloodstream. Interacts w cns alpha4beta2nicotinic recs natural rec = ach. When 2 nicotine bind, ion channel activated: out-compete the recs for ach. Ca, na, k pass thru act pot down axon to brain reward area dopamine released stimulate reward circuit shortlived good feelings. Nicotine eliminated rapidly craving for more dopamine.
