CSB346H1 Lecture Notes - Lecture 6: Sensory Neuron, Afferent Nerve Fiber, Exocytosis

• School: UTSG
• Department: Cell and Systems Biology
• Course: CSB346H1
• Professor: John Peever

Document Summary

Hypoxia causes robust increases in ventilation in humans with intact cbs, but ventilation is unaffected in response to hypoxia after bilateral cb resection. However, cb resection does not abolish ventilatory response to hypercapnia hypercapnia causes increases in ventilation with or without cbs. Hypoxia, hypercapnia, low ph and glucose are cb chemoexcitants. Consists of two major cell types: glomus (type i) and sustentacular (type ii) Glomus cells release dopamine in a ca2+ dependent manner. Spike frequency and neurotransmitter releases are greatly enhanced by hypoxia. O2 release neurotransmitter, which is detected by dendrites of sensory neurons whose cell. Ca2+ entry, and release bodies reside in petrosal ganglion; signal travels through the axon of the sensory neuron via the carotid sinus nerve to the nts, which relays information to rrg to increase ventilation. Glomus cells are excitable and contain k+ channels that are sensitive to o2 levels.