CSB349H1 Lecture Notes - Lecture 4: Histone H3, Dna Supercoil, Ctcf

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20 Sep 2013
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Csb349 lecture 4 welcome to the genome iii: genome structure. Slide 2 organization of dna in the nucleus. The genetic material inside the nucleus has various distinct structures. The major two structures are the heterochromatin and euchromatin. Slide 3 organization of dna in the nucleus. The dna is not just floating around in the nucleus. There is a large and complicated matrix protein that supports the genome: a network of proteins that is holding the genome together and in a loose conformation. The genome is not fixed; it is flexible but it doesn"t move around completely freely. The genes on the chromosome are not randomly interspersed in the nucleus. Each chromosome occupies a distinct region in the nucleus called chromosome territories. Fish experiment fluorescent probes for different chromosomes have been added. The location of the chromosome in the nucleus important for the expression of all the genes (or.

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