Lecture 5

5 Pages

Cell and Systems Biology
Course Code
Mounir Abou Haidar

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Lecture 5 Pages 26 to 35 First 5 minutes of lecture recording not availableIn some plant viruses again the capsid protein of the virus plays a role in the transport of virus Understand this guys Plant viruses plant cells they have walls around them a cell wallHowever cells communicate between each other which means between cells you have doors which means the walls are broken this is only in plants In humananimal cells no wall and cells communicate I send you you send me from place to place But cell wall in bacteria and virusHow do cells move in plants If you have wall how do you move They need someone to transport them they dont have muscle So they use capsid proteinanother protein write in bold EVERY plant virus must code for transport protein special protein only inplant viruses for plants to move Transport protein carries plant RNA from cell to cellthrough door allowing them to communicateIn some cases plant transport proteins they enlarge the door from cell to cell Inside plant cell they unlock the stuff letting it go from cell to cell In some cases viruses whole bunch can go from cell to cellSome capsid proteins not all play role in transport movement from cell to cell also transport protein Strictly for plants Why Otherwise if not plant cells go by current from cell to cell just have membrane between cells You have viruses they coat for a lot of nonstructural proteins Please distinguish bw structural proteins making virus particles the shape ie capsid and nonstructural proteins a whole bunch most make enzymes ie Polymerases have role in replication Thats simple Like RNA polymerases reverse transcriptaseOther proteins have nothing to do with replication have role in regulation for example HIV has proteins like that Rev Tattransactivation of transcription proteins virus make to regulate expression of its own genes these are viral proteins But distinguish bw structural and nonstructuralIn structural can have glycoproteins on surface used mostly to attach virus to cells on receptor binding site Essentially in hundreds of virusesCarbohydrateswe are finished with proteins and glycoproteins Envelope viruses carry glycoproteins glyco means glucose sugar protein have sugars attached to them thats glycoproteins These are normal proteins in virus they have glycosylation signal that is translated by ribosomes genes are in virus but machinery of host ribosomes translate them and if see glycosylation signal ship to membrane of cell
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