Lecture 7

5 Pages
Unlock Document

Cell and Systems Biology
Mounir Abou Haidar

Lecture 7Structurearchitecture of viruses Starting from pg 46 and ending on pg54 Studying the virus structure basically how viruses are built Essentially there are two MAIN kinds of virus structureIcosahedralHelicalOccasionally there are some funnier structures Ex a bullet shaped virus pg 53 which is essentially a helical virus but flat on one side How would you know the structure of a virus There are different methods Pg 46Electron microscopy You magnify them enough by the electron microscope to be able to see them Note Light microscope does not magnify the viruses in order for them to be seen You only see the overall shape of the virus not down to the atomic level Optical Diffraction Not coveredXray Diffraction Very complicated method yet it is the ultimate method for studying the structure of virusesThis will give you the structure down to the structure of the virus not only to the subunit stage but also down to the amino acid and even down to the single atom Nature of Bonding between the capsid protein and the nucleic acid RNADNARememberall the protein subunits building blocks are bonded together by WEAK bonds not covalent since this is the quaternary structure in the protein Why weak interaction Because when the virus enters in the cell it has to dissociate its protein subunits in order to release the RNA DNA for replication If the bonding is strong the RNADNA cant get out therefore there is no need for covalent bonding Note that in simple viruses all the subunits are identical These subunits can make an icosahedral or a helical shaped virus Now the Details pg 47 Note Subunits Capsid protein cp Coat proteinRemember Viruses are made from either RNADNA never both inside a capsidBasic concept Protein subunits ex in Polio an icosahedral virus the protein subunitsinteracting together so that they have the maximum number of possible bondings between the subunits This is the most stable structure which means it is the lowest energy state Icosahedral viruses are mosthappy when they arrange themselves in an icosahedral manner Other viruses the protein structures go around the circle to make a helical structureConclusionSome find themselves most stable in a helical structure some find themselves most stable in an icosahedral structure Therefore WHAT DETERMINES THE STRUCTURE OF A VIRUSITS THE NATURE OF BONDING BETWEEN
More Less

Related notes for CSB351Y1

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.