CSB351Y1 Lecture 17: Lecture 17

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Sample test is posted on the website the last few questions are the more important ones. You lose 5% if you miss the test with a medical note. Picornaviruses polio virus, rhinovirus, hepatitis a virus, coxsackie virus, echo virus. Norwalk virus) and astrovirus (looks like a star) are also (+) rna viruses (details about them are not important for the course) (also, don"t worry about insect and bacterial viruses. Positive/plus (+) rna viruses genomic rna is directly translatable by the ribosomes of eukaryotic cells. In general, (+) rna viruses have a cap (note: not all of them) However, some (+) rna viruses like the picornavirus are not capped at the 5" end. Instead they have a vpg, a small protein, about 22-23 amino acids, hydrophobic, covalently bond to the 5" end. Since these viruses are not capped, they have to find a way of translating their rna .

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