CSB351Y1 Lecture Notes - Fusion Protein, Rna Virus, Memory Stick

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redskunk879

15 Feb 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB351Y1

Professor

Mounir Abou Haidar

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Document Summary

Hemagglutinin (ha) and neuraminidase (na) are glycoproteins on the surface of the envelope of this virus. The lipid portion of the envelope is from the infected cell"s membrane. This virus codes for its own glycoprotein. The neuraminidase (na) is a receptor binding site. This site recognizes sialic acid molecules on the surface of the cells in the respiratory tract. (this allows influenza to recognize respiratory cell"s via na. Influenza attaches to the respiratory cells via ha. Post translational modification: extra modification that occurs after the protein has translated: ha modifications: Now when the virus gets in the host through the fusion protein (ha in this case), the proton pump, which is matrix 2 (m2) protein (saw last class, on test): Once the virus is acidified, it will dissociate from the envelope (uncoat) to dump its rna in the host, to start viral replication. (once have acidification, in the endosome it will induce a conformational change in the ha).

Related Questions

33 Different glycoproteins can have a diverse array of oligosaccharides. Which of the statements below for making glycoproteins on plasma membrane is true?

(a) Extensive modification of oligosaccharides occurs in the extracellular space.

(b) Initial oligosaccharide chains are made by addition of one sugar at a time onto the protein in the ER lumen.

(c) Each layer of Golgi membrane structures contains identical modification enzymes for modifying sugar chain on proteins.

(d) ER lipids can be modified by sugar chain, which can be used for sugar chain modification of the proteins.

peachyak616

Draw the synthesis of an N-glycosylated, integral membrane protein with 3 transmembrane regions, destined for the plasma membrane. (Start with mRNA in the nucleus and end with the protein in the plasma membrane. You do not have to describe all the glycosylation steps, just what is happening in general and where.) In your diagram, be sure to explain with words or show why the carbohydrate groups of membrane glycoproteins always found on the outer surface of the plasma membrane? Think protein expression, not protein function. Be sure to include the different types of protein modifications in the different organelles.

How would this differ for DNA polyermerase?

How would this differ for a soluble protein that functions in the ER that is also methylated?

why does it benefit the african trypanosome (T. Brucei) to maintain more than 1000 genes encoding surface glycoproteins, when only one of these glycoproteins is expressed on the surface of the parasite at any given time

fuchsiazebra340

CSB351Y1 Lecture Notes - Fusion Protein, Rna Virus, Memory Stick

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