CSB351Y1 Lecture : Lecture 27

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redskunk879

15 Feb 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB351Y1

Professor

Mounir Abou Haidar

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Document Summary

Jan 10 2008 lecture 27 red font highlighted in orange highlighted in green when he said remember it indicates different page number. Movie: thurs jan 17 1-2 pm and thurs jan 24 1-2pm: one on influenza virus and 2nd one is ebola virus. Back to measles virus, it is an important virus because it still kills 1 million kids around the world per year. We have vaccine for this virus, we call it mmr mumps, measles, and rubella, these are live attenuated viruses mixed together. You get vaccinated for the 3 viruses at the same time. Measles are antigenic stable therefore it doesn"t change much. Most rna viruses have what we call antigenic drift small mutations here and there, that is normal, that how these viruses change. Antigenic stablility means they are stable for the last 50 yrs or so.

Related Questions

1. Describe the difference between antigenic shift and antigenic drift. Even if you have been vaccinated for the seasonal flu, you still must be vaccinated again next year. Which type of antigenic change does this describe and how does this occur? How might the type of genome (segmented, not segmented) impact the type of antigenic change a virus undergoes?

2. What are the two major groups of retroviruses? Give an example of a lentivirus and explains its structure. What three functions does reverse transcriptase possess?

1. What is the major difference in genome structure between positive-stranded RNA viruses and negative-stranded RNA viruses?

2. What are double-stranded RNA viruses?

3. Explain the role of RNA-dependent RNA polymerase in the life cycle of double stranded RNA viruses.

4. What are the two major antigenic proteins in influenza virus?

5. Why do you think an effective influenza vaccine might not work more than one year to protect you from seasonal flu epidemics?

31)A posotive tuberculin test indicated: a) active tuberculosisb) The person has been infected with tubercle bacilli c)hypersensitivity to tuberculoprotein d) None of the above e) Only Band C above

32)An individual can have several common cold infections over ashort period because: a) Over 100 serologic types of rhinoviruseshave been isolated b) Each type of rhinovirus is immunologicallydistinct c) No immunity results from any virus infection d) All ofthe above e) Only A and B above

33)An effective vaccine against the common cold does not appearfeasible because: a) There are over 100 different rhinoviruses b)There is no immunity to rhinoviruses c) rhinoviruses cannot becultivated insufficient quantity d) Rhinoviruses cannot beattenuated for safe use e) none of the above

34)The most feared complication of mumps is: a) Sterility in themale b) Infertility in the female c) Pneumonia d) Endocarditis e)None of the above

35)Smallpox can be controlled by: a) Antibiotics b) Antiserum c)Vaccintion d) Isolation of infected persons e) none of theabove

36)Which of the following may be spread by respiratorysecretions? a) Measles b) INFLUENZA C) smallpox d) All of the abovee) only A and C above

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CSB351Y1 Lecture : Lecture 27

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