Lecture 31

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University of Toronto St. George
Cell and Systems Biology
Mounir Abou Haidar

P186188Hantavirus 257We started on Hantavirus Im just going to a bit faster through them Hantaviruses belong to the Bunyaviridae The name came from Korea Like the other Bunyaviridae they have 3 pieces of RNA RNA and they have 2 glycoproteins G1 and G2 one for the human infection and one for mice Like other bunyaviridae the reservoir is the wild mice There are talks about capsnatching but its not being proven I wont show it and I wont go over it again There are indications that may be this is happening but its not proven because the replication of these viruses are not sensitive to actinomycin D or alphaamanitin which both drugs are known to inhibit the DNAdependent RNA polymerase of the cell and if you stop the transcription of the mRNA you dont have mRNA of the cell it is known as capsnatching but seems those they dont replicate by any other RNA viruses actinomycin D does not affect any RNA virus replication except influenza because it uses capssnatching you dont have mRNA you donthave cap All other RNA viruses as far as we know they replicate with no problem with actinomycin D and alphaamanitin because they inhibit the DNAdependentRNA polymerase but the virus does not get inhibited Its the DNAdependentRNA polymerase of the cell is inhibited by actinomycin D The other side of the claim why they said that there is capsnatching because they found that the 5 end of the mRNA of those viruses have different sequences which means they must have taken it from somewhere else So its not a conclusive thing so if they have caps snatching or not I dont know so Im not going to ask you this question because we are not sure about 523For the mouse the Hantavirus doesnt do anything before but when infected the mouse they chronically and persistently affect by the hantavirus and the rodent which means the mice they dont show any of all symptoms of the disease Thats a typical reservoir for the virus where the virus can multiply into the animal without causing any of the diseases because it dont have any interest the viruses dont have any interests to kill the animal where they can stay for a long time And the virus is shed by the mice through the feces or through the urineand transmission as I already mentioned through urine saliva and feces and also by aerosols from the urine even the dry urine or dry feces can infect There is no human to human transmission you can have a person dying from Hantavirus but the person next to it cant get it from person to person which is bizarre has to go through the mouse to be infectious As I already mentioned this virus can stay persistently in mice rats and hamsters without any disease symptoms The clinical features of Hantaviruses are quite serious Im going to show you a movie on the Hantavirus next Tuesday or Thursday location TBA The clinical features of the hantaviruses all of them are two general kinds of
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