CSB351Y1 Lecture Notes - Orthohantavirus, Rodent, Phlebovirus

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redskunk879

15 Feb 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB351Y1

Professor

Mounir Abou Haidar

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Document Summary

We started on hantavirus, i"m just going to a bit faster through them. Like the other bunyaviridae they have 3 pieces of rna, -rna, and they have 2 glycoproteins: g1 and g2, one for the human infection and one for mice. Like other bunyaviridae, the reservoir is the wild mice. There are talks about cap- snatching, but it"s not being proven, i won"t show it and i won"t go over it again. There are indications that may be this is happening but it"s not proven because the replication of these viruses are not sensitive to actinomycin d or alpha-amanitin which both drugs are known to inhibit the dna-dependent . All other rna viruses, as far as we know, they replicate with no problem with actinomycin d and alpha-amanitin because they inhibit the dna-dependent-rna polymerase, but the virus does not get inhibited. As i already mentioned, this virus can stay persistently in mice, rats and hamsters without any disease symptoms.

Related Questions

Orthomyxoviruses (influenza) and picornaviruses (polio) are both RNA viruses that encode their own RNA polymerase. However, Orthomyxoviruses mRNA synthesis requires the activity of the host RNA polymerase II, whereas picornavirus mRNA synthesis does not. Discuss this observation in the context of the two basic types of priming mechanism used by RNA-dependent RNA polymerases?

Mechanisms ==> 1-protein-linked oligonucleotide. 2- Cap-snatching

QUESTION 1: The rabies virus primarily affects the nervous system. The specificity that the rabies virus has for neuronal host cells is primarily dictated by __________________________.

A. the helical shape of its viral capsid

B. the type of nucleic acid used for its viral genome (single-stranded, antisense RNA)

C. the spikes that protrude from its viral envelope

D. the segmented nature of its viral genome

QUESTION 2: Which of the following genome types has been observed in viruses? To be marked correct, you'll need to select all true statements, as there may be more than one correct answer.

A. Single-stranded RNA

B. Single-stranded DNA

C. Double-stranded RNA

D. Protein-based

QUESTION 3: Choose the correct statement about viral evolution.

A. RNA and DNA viral genomes evolve at equal rates.

B. Cellular genomes mutate at a faster rate than viral genomes due to their large size and increased chance of replicative mistakes.

C. DNA viruses mutate faster than RNA viruses because thymine is more susceptible to mutation than uracil.

D. RNA viruses mutate faster than DNA viruses due to a lack of proofreading replicative enzymes.

QUESTION 4: Your elderly patient is affected by shingles. After careful observation, you note that the virus responsible for the infection has an icosahedral capsid, is enveloped, and has double-stranded linear DNA as its genetic material. Based on this information, in which of the following viral families would you group this viral pathogen?

QUESTION 5: Which of the following is a key difference between lytic and lysogenic bacteriophage replication cycles?

A. Lysogenic bacteriophages release via host cell lysis, whereas lytic bacteriophages bud off from the host cell membrane.

B. The lytic replication cycle ends with host cell lysis and release of newly formed bacteriophage particles, whereas lysogenic replication leads to prophage formation.

C. Lytic replication requires an uncoating step, whereas in lysogenic replication, the bacteriophage's nucleic acid is directly injected into the host cell.

D. Whereas lytic replication enables the infection of several hosts, lysogenic replication only allows for infection of a single host cell.

QUESTION 6: Which of the following is an unsuitable culture method for an animal virus?

A. Direct inoculation of virus onto blood agar

B. Live animal inoculation

C. Tissue culture method

D. Injection of virus into embryonated eggs

1A) Why is it difficult to prepare an effective vaccine against RNA viruses with segmented genomes?

B) What were the problems with earlier versions of Rotavirus that required its withdrawal from the market?

C) What is unique about Rotavirus replication?

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CSB351Y1 Lecture Notes - Orthohantavirus, Rodent, Phlebovirus

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