CSB447H1 Lecture Notes - Lecture 4: Pyruvate Dehydrogenase Complex, Nadh Dehydrogenase, Succinic Acid
Document Summary
Lecture 4: mitochondrial metabolism: anatomy of a cell, mitochondria has 2 membranes, outer membrane: relatively permeable and large, many compounds can pass through it. Inner membrane: tight membrane, things do not pass through easily. Primarily pumps protons out of mitochondrial matrix = matrix is basic, cytosol is acidic. The fof1-atpase: atp synthase making atp with it. The large proton gradient helps in driving the synthesis of atp: david keilin"s ca. In working conditions, cytochromes became more oxidized oxidation and reduction in cytochromes: electron transport system (ets) and. The electron transport chain is the final stage of aerobic respiration leading to the forming of atp in the inner membrane of the mitochondrion. Complex 1: nadh dehydrogenase: the electrons from here do not necessarily go to the succinate dehydrogenase complex. Since molecular oxygen is diatomic, it actually takes two electron pairs and two cytochrome oxidase complexes to complete the reaction sequence for the reduction of oxygen.
