CSB327H1 Lecture Notes - Lecture 14: Basal Lamina, Dystroglycan, Syndecan
1 Jan 2014
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Lecture 14 - laminin family and epithelial morphogenesis. Connective tissues e. g. blood, cartilage, bone, liver, dermis: have both basal lamina and interstitial matrices. Assembly of laminin @ co-expression of other components allow for integration into basal lamina. Laminin"s the star, ko of t4c = still have bl structure, laminin ko = no basal lamina. In addition to tensile strength, t4c dictates the shape of the cell, perlecan controls how much tensile strength t4c will impose. Laminin needs to be in basal lamina to promote co-assembly of these molecules bc it binds all basement membrane proteins (t4c, perlecan, nidogen) along /w itself. Nomenclature: used to be based on individual a1 composition - this is not the case anymore. Proper nomenclature starts /w alpha # and then possible combos of b/y y1 chain is common to most heterotrimers. Lm-1 (111,121) is first embryonic form that"s made; ko of lm-1 is embryonic lethal and will inhibit development at pre-implantation of uterine wall.
