CSB327H1 Lecture Notes - Lecture 3: Lysyl Oxidase, Ultimate Tensile Strength, Fibril
Document Summary
Bones mineralize by the formation of hydroxyapatite crystals in the hole zone (fibril flexibility) Need incredible precision in collagen molecule and supramolecular assembly. Type i collagen gives tissues mechanical strength (better than steel) A lot of crosslinking inside the cell. ***result*** molecule doesn"t integrate into fibrils, usually lethal. 1) intermolecular (usually, between n and c terminae) 2) linked at telopeptide domains (modified lys or oh-lys chain) 4) side-by-side stabilized by aldol cross-links (excessive glycosylation prevents the deanimation back to aldehydes) D period is the gap that you have in the staggering and the overlap of adjacent collagen molecules. See repeat because theirs a gap in the staggering of crosslinked fibrils. Hole zone: traps the most dye, 0. 6d (hole from c to n terminae) Collagen turns over about every 6 months (scurvy highlights this) Metalloproteines cannot touch collagen except for collagenases (special mmps that attack triple helix) (due to intimate wrapping) Cancer: activate mmps to remodel matrix to allow their proliferation.
