CSB327H1 Lecture Notes - Lecture 5: Basal Lamina, Tight Junction, Neural Crest

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16 Oct 2014
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Section title: epithelial cells: polarized, sits on the basil lamina, golgi at apical, mesenchymal cells: spindle shaped, single cell surrounded by. Ecm, golgi at the leading edge embryogenesis: epithelia mesenchymal. Emt fated cell has to have it"s basal lamina dissolved by metalloproteinases. Met fated cells start to synthesize basal lamina components. Inner cell mass (embryonic stem cells, what forms the embryo) Embryonic stem cells do not differentiate in the presence of leukocyte inhibitory factor (lif) Remove lif from a inner cell mass derived esc. Differentiation occurs: endoderm is on the outside (forms before basal lamina) Then a basal lamina is made:primitive ectoderm is on the inside. Then the embryo forms an amniotic cavity in the middle. This is dependant on polarization of the primitive ectoderm into an epithelial state (basal lamina is needed for this!!) Laminin is essential for epiblast polarization!! (b. m. is visible by laminin staining and collagen iv staining) Importance of hsp47 in the organization of embryoid.

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