CSB349H1 Lecture Notes - Lecture 2: Neofunctionalization, Gene Duplication, Globin
28 Aug 2019
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Document Summary
Vast majority of our genes come from gene duplication. Cdc14b gene has exons and alternative exons (utr untranslated region that is made into rna but is untranslated) There is another copy being made cdc14b retrogene where it does not contain any introns (solid big coding exon) with utrs. This gene in the dna represent exactly one of the mrnas that were made from the original gene. One of the mrnas (alternative splicing) got mixed up with retrovirus machinery, got converted to cdna and inserted somewhere else in the genome 2 different copies of the gene cdc14b (redundant) Genes subfunctionalized (gene function split between 2 copies instead of one gene doing both functions: selective pressure on both genes. Gene stays similar (same functions, sometimes: selective pressure on just one of the genes i (most) One copy degrades/gets lost: selective pressure on just one of the genes ii (usually) Neofunctionalization mutation where duplicated gene gets new function.
