CSB351Y1 Lecture Notes - Orthohantavirus, Rodent, Phlebovirus
Document Summary
We started on hantavirus, i"m just going to a bit faster through them. Like the other bunyaviridae they have 3 pieces of rna, -rna, and they have 2 glycoproteins: g1 and g2, one for the human infection and one for mice. Like other bunyaviridae, the reservoir is the wild mice. There are talks about cap- snatching, but it"s not being proven, i won"t show it and i won"t go over it again. There are indications that may be this is happening but it"s not proven because the replication of these viruses are not sensitive to actinomycin d or alpha-amanitin which both drugs are known to inhibit the dna-dependent . All other rna viruses, as far as we know, they replicate with no problem with actinomycin d and alpha-amanitin because they inhibit the dna-dependent-rna polymerase, but the virus does not get inhibited. As i already mentioned, this virus can stay persistently in mice, rats and hamsters without any disease symptoms.