CSB351Y1 Lecture Notes - Rna Virus, Intergenic Region

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redskunk879

15 Feb 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB351Y1

Professor

Mounir Abou Haidar

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Document Summary

*recording starts a bit into the lecture; missing section on hepatitis g page 221 however he didn"t go into much detail, and from my notes all he said was: Similar symptoms to hepatitis c; can be chronic. The corona virus look like a crown with jewels around it, is isohedral with glycoproteins; i used to cover the corona virus until the sars virus. Usually the corona can cause respiratory and gi problem, diarrhea, benign cold, those types of things, until this new strain of the virus, the sars cov, cov stands for corona virus, the outbreak in canada had about 42 dead. Originally came from china; the sars is from a cat, mixed human and cats, then got back to humans. It is avian and human mix, mixed in the cevid cat (wild cat) It has a surface s protein attached to the membrane, endocytosis, nothing new, replication in the cytoplasm, like all other (+) rna viruses with envelope.

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Patient

32 year-old female with a history of poly-substance abuse, including IV drug use, who presented at the ER with fever, abdominal pain, nausea, vomiting, headaches and myalgia (muscle pain). She also had toothache for which she had taken approximately 50 acetaminophen tablets over a 24 hour period. She was transferred to a medical center ER for the acetaminophen overdose.

Physical exam showed patient alert and oriented with normal vital signs. Right upper quadrant pain was noted, as well as mild jaundice.

Diagnostic

Laboratory testing indicated the following liver function tests and other tests:

AST	ALT	GGT	LDH	BUN	Creatinine	Acetaminophen
791 U/liter	1,398 U/liter	166 U/liter	826 U/liter	83 mg/dl	10.1 mg/dl	15Âµg/ml

Hepatitis A IgM	Hepatitis A IgG	Hepatitis B Surface Antigen	Hepatitis B Surface Antibody	Hepatitis B Core IgM	Hepatitis C Total (IgM/IgG)
Negative	Negative	Negative	Negative	Negative	Positive

Her hospital course was significant for acute renal and liver failure, with improvement after dialysis was performed.

Based on the patientâs history, presenting symptoms and LFT results, which of the following viruses would be most likely to be the problem?

BK virus

JC virus

Hepatitis B or C

CMV

After reviewing the serologic test results, which organism is the causative virus?

Hepatitis B

Hepatitis C

Hepatitis A

Hepatitis D

What are the modes of transmission for this virus? Which was most likely in this case?

Based on how she was infected, would she be at risk for any other viral infections? Which ones?

Why would it be important to determine the genotype of the virus with which she is infected?

If she had received a vaccination for the virus, would this infection have been prevented? Why or why not?

please i need an answer for all of these questions. this is due 10/19.

Physical exam showed patient alert and oriented with normal vital signs. Right upper quadrant pain was noted, as well as mild jaundice.

Diagnostic

Laboratory testing indicated the following liver function tests and other tests:

AST	ALT	GGT	LDH	BUN	Creatinine	Acetaminophen
791 U/liter	1,398 U/liter	166 U/liter	826 U/liter	83 mg/dl	10.1 mg/dl	15Âµg/ml

Hepatitis A IgM	Hepatitis A IgG	Hepatitis B Surface Antigen	Hepatitis B Surface Antibody	Hepatitis B Core IgM	Hepatitis C Total (IgM/IgG)
Negative	Negative	Negative	Negative	Negative	Positive

Her hospital course was significant for acute renal and liver failure, with improvement after dialysis was performed.

Based on the patientâs history, presenting symptoms and LFT results, which of the following viruses would be most likely to be the problem?

BK virus

JC virus

Hepatitis B or C

CMV

After reviewing the serologic test results, which organism is the causative virus?

Hepatitis B

Hepatitis C

Hepatitis A

Hepatitis D

What are the modes of transmission for this virus? Which was most likely in this case?

Based on how she was infected, would she be at risk for any other viral infections? Which ones?

Why would it be important to determine the genotype of the virus with which she is infected?

If she had received a vaccination for the virus, would this infection have been prevented? Why or why not?

please i need an answer for all of these questions. this is due 10/19.

Hepatitis C is a chronic liver infection that can be either silent (with no noticeable symptoms) or debilitating. Either way, 80% of infected persons experience continuing liver destruction. Chronic hepatitis C infection is the leading cause of liver transplants in the United States. The virus that causes it is blood borne, and therefore patients who undergo frequent procedures involving transfer of blood are particularly susceptible to infection. Kidney dialysis patients belong to this group. In 2008, a for-profit hemodialysis facility in New York was shut down after nine of its patients were confirmed as having become infected with hepatitis C while undergoing hemodialysis treatments there between 2001 and 2008.

When the investigation was conducted in 2008, investigators found that 20 of the facilityâs 162 patients had been documented with hepatitis C infection at the time they began their association with the clinic. All the current patients were then offered hepatitis C testing, to determine how many had acquired hepatitis C during the time they were receiving treatment at the clinic. They were considered positive if enzyme-linked immunosorbent assay (ELISA) tests showed the presence of antibodies to the hepatitis C virus.

Health officials did not test the workers at the hemodialysis facility for hepatitis C because they did not view them as likely sources of the nine new infections. Why not?

Why do you think patients were tested for antibody to the virus instead of for the presence of the virus itself

blushkoala457

CSB351Y1 Lecture Notes - Rna Virus, Intergenic Region

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